反应详情

To a solution of 1.26 g (2.61 mmol) of 7-[4-(imidazo-[1,2-a]pyridin-5-ylthio)butyl]-1,1-dioxo-9-phenyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione in 20 ml of methanol, 0.25 ml (3 mmol) of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, diethyl ether was added to the residue. The resulting crystal was collected by filtration and dried to yield 1.35 g (quant, light white crystal) of the desired product.

1. concentrationAfter the reaction mixture was concentrated to dryness, diethyl ether
2. additionwas added to the residue
3. filtrationThe resulting crystal was collected by filtration
4. customdried