Hydrogen chloride-ethyl acetate → HCID 73472935, compound

HRID 357080Notes

Reaction equation

HRID 357080 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][N:17]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4].[ClH:26].C(OCC)(=O)C>CO>[ClH:26].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][N:17]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57015719HCID 57015719, compound

Product 1

HCID 73472935HCID 73472935, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 1.052 g (2.79 mmol) of 5-butylidene-3-[4-(imidazo[1,2-c]pyrimidin-5-ylthio)butyl]thiazolidine-2,4-dione, 3 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring, after which the solvent was distilled off, to yield 0.914 g (79.3%, white powder) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-40d9360bb7174371825797e59edf489d
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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