Hydrochloric Acid → 5-Butylidene-3-[4-(2-ethoxycarbonylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357084Notes

Reaction equation

HRID 357084 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[C:23]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:30])[CH2:2][CH2:3][CH3:4].[ClH:31]>CO>[ClH:31].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[C:23]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:30])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 570343035-Butylidene-3-[4-(2-ethoxycarbonylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729265-Butylidene-3-[4-(2-ethoxycarbonylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2.14 g (4.96 mmol) of 5-butylidene-3-[4-(2-ethoxycarbonylimidazo[1,2-a]pyridin-8-yloxy)butyl]-thiazolidine-2,4-dione in 20 ml of methanol, 0.45 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 2.07 g (89.2%, yellow oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-95f550719e4345a2a76ab28f25377da4
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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