Hydrochloric Acid → 5-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride

HRID 357088Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 357088
[N:1]1([CH:7]=[C:8]2[S:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]3[N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH:22]=[CH:21][CH:20]=3)[C:9]2=[O:28])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:29]>CO>[ClH:29].[ClH:29].[N:1]1([CH:7]=[C:8]2[S:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]3[N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH:22]=[CH:21][CH:20]=3)[C:9]2=[O:28])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 539811735-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

Produkt 1

HCID 734729745-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 220 mg (0.526 mmol) of 5-(piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-thiazolidine-2,4-dione in 10 ml of methanol, concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 218 mg (56.2%, white powder) of the desired product.

Aufarbeitung

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f2064200e2844891921a6d8988fb5693
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840732

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