HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione | HCID 53981173 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione dihydrochloride | HCID 73472974 | — |
Reaction Steps
To a solution of 220 mg (0.526 mmol) of 5-(piperidin-1-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-thiazolidine-2,4-dione in 10 ml of methanol, concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 218 mg (56.2%, white powder) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05840732 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-f2064200e2844891921a6d8988fb5693 |
| Source note | uspto-grants-1998_11 |