反应详情

A mixture of 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane (4.86 g) prepared as described in Example 1, hydroxylamine hydrochloride (1.6 g), sodium acetate trihydrate (3.3 g), industrial methylated spirit (15 ml) and water (2 ml) was heated under reflux for twenty hours. The cooled reaction mixture was poured into water and the oil which separated was cooled to give a solid which was recrystallised from industrial methylated spirit to give 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime (m.p. 120°-121° C.).

1. customprepared
2. temperaturewas heated
3. temperatureunder reflux for twenty hours
4. customThe cooled reaction mixture
5. customthe oil which separated
6. temperaturewas cooled
7. customto give a solid which
8. customwas recrystallised from industrial methylated spirit