Hydrochloric Acid → HCID 73472899, compound

HRID 357098Notes

Reaction equation

HRID 357098 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[C:22]([C:25](=[O:30])[C:26]([F:29])([F:28])[F:27])=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4].[ClH:32]>CO>[ClH:32].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[C:22]([C:25](=[O:30])[C:26]([F:29])([F:28])[F:27])=[CH:23][N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57103741HCID 57103741, compound

Product 1

HCID 73472899HCID 73472899, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 200 mg (0.42 mmol) of 5-butylidene-3-[4-(3-trifluoroacetylimidazo[1,2-a]pyridin-5-ylthio)butyl]-thiazolidine-2,4-dione in 5 ml of methanol, 0.1 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 220 mg (100%, yellow oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-4e08d02027e7440e8533d58ce6391fe8
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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