Hydrochloric Acid → HCID 18936758, compound

HRID 357101Notes

Reaction equation

HRID 357101 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:20](=[O:21])[C:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[C:18]4[S:28](=[O:32])(=[O:31])[CH2:29][CH2:30][N:17]4[C:16]3=[O:33])=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:34]>CO>[ClH:34].[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:20](=[O:21])[C:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[C:18]4[S:28](=[O:32])(=[O:31])[CH2:29][CH2:30][N:17]4[C:16]3=[O:33])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18936666HCID 18936666, compound

Product 1

HCID 18936758HCID 18936758, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 400 mg (0.85 mmol) of 6-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-1,1-dioxo-8-phenyl-2,3-dihydro-5H-thiazolo-[3,2-c]pyrimidine-5,7(6H)-dione in 20 ml of methanol, 0.10 ml of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, diethyl ether was added to the residue. The resulting crystal was collected by filtration and dried to yield 430 mg (97.4%, light white powder) of the desired product.

Workup

  1. concentrationAfter the reaction mixture was concentrated to dryness, diethyl ether
  2. additionwas added to the residue
  3. filtrationThe resulting crystal was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-49c7d38980904ab680eec3b6d8e55734
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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