Hydrochloric Acid → HCID 86753347, compound

HRID 357102Notes

Reaction equation

HRID 357102 reaction equation
[O:1]=[S:2]1(=[O:36])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:35])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[S:34])[CH2:24][C:25]3[N:30]4[CH:31]=[CH:32][N:33]=[C:29]4[CH:28]=[CH:27][CH:26]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12.[ClH:37]>CO>[ClH:37].[O:36]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:35])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[S:34])[CH2:24][C:25]3[N:30]4[CH:31]=[CH:32][N:33]=[C:29]4[CH:28]=[CH:27][CH:26]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53734589HCID 53734589, compound

Product 1

HCID 86753347HCID 86753347, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 390 mg (0.72 mmol) of imidazo[1,2-a]pyridin-5-ylthioacetic acid [3-(1,1,6,8-tetraoxo-9-phenyl-2,3,4,8-tetrahydro-pyrimido[6,1-b][1,3]thiazin-7-yl)propyl]amide in 10 ml of methanol, 0.07 ml (0.85 mmol) of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, the residue was washed with diethyl ether to yield 370 mg (89.2%, white solid) of the desired product.

Workup

  1. concentrationAfter the reaction mixture was concentrated to dryness
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-4cf192a7fb4c4bc182f4f06b05e544db
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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