反应详情

To 16.8 ml of 50% ethanol, 78.7 ml (844 mmol) of phosphorus oxychloride was added drop by drop, with stirring under ice cooling conditions. To this solution, 30.83 g (100 mmol) of 3,5-dibenzylpyrimidine-2,4,6(1H,3H)-trione was added little by little. This mixture was stirred at 50° C. for 30 minutes and then at 100° C. for 90 minutes. After cooling, the reaction mixture was poured into ice water and stirred for 1 hour. The resulting precipitate was collected by filtration, washed with water and n-hexane and dried to yield 32.62 g (99.8%, light white crystal) of the desired product.

1. stirringThis mixture was stirred at 50° C. for 30 minutes
2. temperatureAfter cooling
3. stirringstirred for 1 hour
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with water and n-hexane
6. customdried