Hydrochloric Acid → HCID 18936687, compound

HRID 357120Notes

Reaction equation

HRID 357120 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:26](=[O:27])[C:25]([CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[C:18]4[S:19](=[O:24])(=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:35])=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:36]>CO>[ClH:36].[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:26](=[O:27])[C:25]([CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[C:18]4[S:19](=[O:24])(=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:35])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18936688HCID 18936688, compound

Product 1

HCID 18936687HCID 18936687, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.95 g (3.91 mmol) of 7-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-1,1-dioxo-9-benzyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione in 20 ml of methanol, 0.5 ml (6 mmol) of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, diethyl ether was added to the residue. The resulting crystal was collected by filtration and dried to yield 1.90 g (90.8%, light white crystal) of the desired product.

Workup

  1. concentrationAfter the reaction mixture was concentrated to dryness, diethyl ether
  2. additionwas added to the residue
  3. filtrationThe resulting crystal was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-8627d349a4fc47dfa92190e21155c13a
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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