Hydrochloric Acid → HCID 18936754, compound

HRID 357134Notes

Reaction equation

HRID 357134 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:26](=[O:27])[CH:25]=[C:18]4[S:19](=[O:24])(=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:28])=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:29]>CO>[ClH:29].[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:26](=[O:27])[CH:25]=[C:18]4[S:19](=[O:24])(=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:28])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18936701HCID 18936701, compound

Product 1

HCID 18936754HCID 18936754, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.442 g (1.05 mmol) 7-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-1,1-dioxo-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione in 15 ml of methanol, 0.3 ml (3.5 mmol) of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, diethyl ether was added to the residue. The resulting crystal was collected by filtration and dried to yield 0.405 g (84.3%, light white crystal) of the desired product.

Workup

  1. concentrationAfter the reaction mixture was concentrated to dryness, diethyl ether
  2. additionwas added to the residue
  3. filtrationThe resulting crystal was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-7f4cae4b065b48ff900db4cf6d0b8ad2
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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