反应详情

To a slurry of 28.7 g. of N-t-butoxycarbonyl-L-alanyl-D-alanine benzyl ester in 150 ml. of dioxane saturated with hydrogen chloride and the mixture stirred for 4 hours at room temperature. The solvent was removed in vacuo and the residue triturated with diethyl ether. The resulting solids were filtered, redissolved in methylene chloride and the solution concentrated to about 150 ml. Ether was added and the solids filtered under nitrogen, 22.0 g.

1. customThe solvent was removed in vacuo
2. customthe residue triturated with diethyl ether
3. filtrationThe resulting solids were filtered
4. dissolutionredissolved in methylene chloride
5. concentrationthe solution concentrated to about 150 ml
6. additionEther was added
7. filtrationthe solids filtered under nitrogen