Hydrochloric Acid → HCID 73472958, compound

HRID 357143Notes

Reaction equation

HRID 357143 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([C:18]2[N:23]3[CH:24]=[CH:25][N:26]=[C:22]3[CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:6]1=[O:27])[CH2:2][CH2:3][CH3:4].[ClH:28]>CO>[ClH:28].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([C:18]2[N:23]3[CH:24]=[CH:25][N:26]=[C:22]3[CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:6]1=[O:27])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57237920HCID 57237920, compound

Product 1

HCID 73472958HCID 73472958, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 269 mg (0.66 mmol) of 5-butylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylsulfonyl)butyl]thiazolidine-2,4-dione in 10 ml of methanol, 0.10 ml of concentrated hydrochloric acid was added, followed by stirring, after which the solvent was distilled off. The residue was washed with diethyl ether to yield 304 mg (quant., yellow oily substance) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off
  2. washThe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-0de4dae01aec46ffad7e4623960bbe2d
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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