Hydrochloric Acid → HCID 73472953, compound

HRID 357150Notes

Reaction equation

HRID 357150 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[C:23]([CH3:25])[N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4].[ClH:27]>CO>[ClH:27].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[C:23]([CH3:25])[N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57040647HCID 57040647, compound

Product 1

HCID 73472953HCID 73472953, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.23 g (3.29 mmol) of 5-butylidene-3-[4-(2-methylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione in 30 ml of methanol, 0.33 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.41 g (quant., yellow oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-5aaf80058114435781e5c89ce9dda58f
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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