Hydrochloric Acid → HCID 18936802, compound

HRID 357155Notes

Reaction equation

HRID 357155 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:25](=[O:26])[C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[C:18]4[S:19](=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:33])=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:34]>CO>[ClH:34].[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:25](=[O:26])[C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[C:18]4[S:19](=[O:23])[CH2:20][CH2:21][CH2:22][N:17]4[C:16]3=[O:33])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18936776HCID 18936776, compound

Product 1

HCID 18936802HCID 18936802, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 166 mg (0.36 mmol) of 7-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-1-oxo-9-phenyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione in 5 ml of methanol, 8 μl of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 132 mg (72.9%, light yellow foamy substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-3a4fb42d90f64834a311e1d867c40edb
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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