5-(4-Chlorophenyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione → 5-(4-Chlorophenyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

HRID 357177Notes

Reaction equation

HRID 357177 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9]2[O:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][S:19][C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[CH:22][CH:21]=3)[C:10]2=[O:29])=[CH:4][CH:3]=1>CO.Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[C:9]2[O:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][S:19][C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[CH:22][CH:21]=3)[C:10]2=[O:29])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 543485705-(4-Chlorophenyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione

Product 1

HCID 702053545-(4-Chlorophenyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

To a solution of 0.301 g (0.70 mmol) of 5-(4-chlorophenyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione in 10 ml of methanol, 0.10 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was crystallized by the addition of diethyl ether to yield 0.223 g (68.6%, light pink crystal) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized by the addition of diethyl ether

Sources & evidence

ORD record
ord-ddfa37448dd64177b4b7a815fc9c0367
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

Loading…