Hydrochloric Acid → HCID 86753350, compound

HRID 357184Notes

Reaction equation

HRID 357184 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[C:8]1[S:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]2[N:24]3[CH:25]=[CH:26][N:27]=[C:23]3[CH:22]=[CH:21][CH:20]=2)[C:9]1=[O:28].[ClH:29]>CO>[ClH:29].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[C:8]1[S:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]2[N:24]3[CH:25]=[CH:26][N:27]=[C:23]3[CH:22]=[CH:21][CH:20]=2)[C:9]1=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53716598HCID 53716598, compound

Product 1

HCID 86753350HCID 86753350, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.483 g (3.61 mmol) of 5-(2-pyridyl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 30 ml of methanol, 0.42 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was crystallized from dichloromethane-diethyl ether to yield 1.61 g (99.8%, white crystal) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from dichloromethane-diethyl ether

Sources & evidence

ORD record
ord-4bc03ea9994741a4b152a200481a53b9
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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