Hydrogen chloride-ethyl acetate → HCID 73472956, compound

HRID 357190Notes

Reaction equation

HRID 357190 reaction equation
[CH:1](=[C:7]1[S:11][C:10](=[O:12])[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[C:19]3[N:20]([CH:24]=[CH:25][N:26]=3)[CH:21]=[CH:22][CH:23]=2)[C:8]1=[O:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[ClH:28].C(OCC)(=O)C>CO>[ClH:28].[CH:1](=[C:7]1[S:11][C:10](=[O:12])[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[C:19]3[N:20]([CH:24]=[CH:25][N:26]=3)[CH:21]=[CH:22][CH:23]=2)[C:8]1=[O:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57306057HCID 57306057, compound

Product 1

HCID 73472956HCID 73472956, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 1.73 g (4.5 mmol) of 5-hexylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione, 1 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring. After the solvent was distilled off, the residue was washed with ether to yield 1.73 g of an oily substance, which was then purified by recrystallization to yield 1.58 g (74%, white crystal) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with ether
  3. customto yield 1.73 g of an oily substance, which
  4. customwas then purified by recrystallization

Sources & evidence

ORD record
ord-f0730112f55d445498540d35303a9fc1
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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