Hydrogen chloride-ethyl acetate → HCID 73472917, compound

HRID 357191Notes

Reaction equation

HRID 357191 reaction equation
[CH:1](=[C:9]1[S:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]2[C:21]3[N:22]([CH:26]=[CH:27][N:28]=3)[CH:23]=[CH:24][CH:25]=2)[C:10]1=[O:29])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[ClH:30].C(OCC)(=O)C>CO>[ClH:30].[CH:1](=[C:9]1[S:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]2[C:21]3[N:22]([CH:26]=[CH:27][N:28]=3)[CH:23]=[CH:24][CH:25]=2)[C:10]1=[O:29])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57285747HCID 57285747, compound

Product 1

HCID 73472917HCID 73472917, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 2.03 g (4.9 mmol) of 5-octylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione, 1.25 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring. After the solvent was distilled off, the residue was washed with ether to yield 1.71 g (77.2%, white solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with ether

Sources & evidence

ORD record
ord-75849eb729e24be69f0f0c4cbc2b1df1
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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