Hydrogen chloride-ethyl acetate → HCID 70205491, compound

HRID 357200Notes

Reaction equation

HRID 357200 reaction equation
[O:1]=[S:2]1(=[O:36])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:35])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:34])[CH2:24][C:25]3[N:30]4[CH:31]=[CH:32][N:33]=[C:29]4[CH:28]=[CH:27][CH:26]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12.[ClH:37].C(OCC)(=O)C>CO>[ClH:37].[O:36]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:35])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:34])[CH2:24][C:25]3[N:30]4[CH:31]=[CH:32][N:33]=[C:29]4[CH:28]=[CH:27][CH:26]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 53634368HCID 53634368, compound

Product 1

HCID 70205491HCID 70205491, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 75 mg (0.15 mmol) of imidazo[1,2-a]pyridin-5-acetic [3-(1,1,6,8-tetraoxo-9-phenyl-2,3,4,8-tetrahydropyrimido[6,1-b][1,3]thiazine-7-yl)propyl]amide, 0.1 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring, after which the solvent was distilled off, to yield 75 mg (92.0%, light yellow oily substance) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-5e7705222da641f48ddc89624a949fc4
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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