HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-(4-Fluorophenyl)-5-(4-methylsulfonylphenyl)-2-methylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Thioacetamide | HCID 2723949 | — |
| Reactant | 2-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone | HCID 11234079 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Fluorophenyl)-5-(4-methylsulfonylphenyl)-2-methylthiazole | HCID 10172237 | 31.1% |
Reaction Steps
To 2-bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-ethanone (1.10 g) in ethanol (15.0 mL) were added thioacetamide (0.266 g) and pyridine (0.300 mL). After refluxing for 2 h, the reaction mixture was extracted with EtOAc, 25% NH4OAc and purified by flash chromatography (50% EtOAc in hexane then 90% Et2O in hexane) to yield the title compound (0.320 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05840746 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-3403f308599a499b9ff0106056a4e395 |
| Source note | uspto-grants-1998_11 |