反应详情

To 2-bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-ethanone (1.10 g) in ethanol (15.0 mL) were added thioacetamide (0.266 g) and pyridine (0.300 mL). After refluxing for 2 h, the reaction mixture was extracted with EtOAc, 25% NH4OAc and purified by flash chromatography (50% EtOAc in hexane then 90% Et2O in hexane) to yield the title compound (0.320 g).

1. temperatureAfter refluxing for 2 h
2. extractionthe reaction mixture was extracted with EtOAc, 25% NH4OAc
3. custompurified by flash chromatography (50% EtOAc in hexane