Ethylene Glycol → HCID 15790821, compound

HRID 357537Notes

Reaction equation

HRID 357537 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[CH2:16][C:15](C=O)([C:17]#[N:18])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].[CH2:21]([OH:24])[CH2:22][OH:23].[C:25]1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH:25]3[O:24][CH2:21][CH2:22][O:23]3)=[C:15]([C:17]#[N:18])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:9])[F:10]

Participants

6

Reactant 4

HCID 174Ethylene GlycolHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 131720956HCID 131720956, compound

Product 1

HCID 15790821HCID 15790821, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.6 g (2.0 mmol) 1-(4-chlor-5-difluormethoxy-1-methyl-3-pyrazolyl)-4-formyl-4pyrazol-carbonitrile is dissolved in 30 ml toluene and 0.14 g (2.2 mmol) ethylene glycol and a catalytic amount of p-toluene sulphonic acid are added. The mixture is heated for 2 hours on the water-separator, the cooled solution is washed with sodium chloride solution, and it is then dried and concentrated.

Workup

  1. washthe cooled solution is washed with sodium chloride solution, and it
  2. customis then dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b6af0f106170466f801eb7382314fda4
Source dataset
uspto-grants-1998_11
Patent number
US05840912

Reaction notes

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