HCID 54002888, compound → HCID 15166324, compound

HRID 357565Notes

Reaction equation

HRID 357565 reaction equation
CS(O[CH2:6][C:7]1[C:12]([CH3:13])=[C:11]([O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21])[C:10]([CH3:22])=[CH:9][N:8]=1)(=O)=O.[SH:23][C:24]1[NH:25][C:26]2[CH:32]=[CH:31][CH:30]=[CH:29][C:27]=2[N:28]=1>C(O)C>[CH3:21][O:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][C:11]1[C:10]([CH3:22])=[CH:9][N:8]=[C:7]([CH2:6][S:23][C:24]2[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[N:25]=2)[C:12]=1[CH3:13]

Participants

4

Reactant 2

HCID 54002888HCID 54002888, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 15166324HCID 15166324, compoundYield 26.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture comprising 3.0 g of {4-(2-methoxyethoxy)ethoxy-3,5-dimethylpyridine-2-yl}methyl methanesulfonate, 1.17 g of 2-mercaptobenzimidazole and 30 ml of ethanol was stirred at a room temperature for one hour and distilled to remove the ethanol. The residue was purified by silica gel column chromatography to obtain 0.8 g of the title compound.

Workup

  1. distillationdistilled
  2. customto remove the ethanol
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-bbb2b72d7702454e86ce20965938a022
Source dataset
uspto-grants-1998_11
Patent number
US05840910

Reaction notes

Loading…