Hydrochloric Acid → 1,2-Diamino-4-ethyl-imidazole hydrochloride

HRID 357609Notes

Reaction equation

HRID 357609 reaction equation
[NH2:1][C:2]1[N:3]([N:9]=CC2C=CC=CC=2)[CH:4]=[C:5]([CH2:7][CH3:8])[N:6]=1.[ClH:17]>>[ClH:17].[NH2:9][N:3]1[CH:4]=[C:5]([CH2:7][CH3:8])[N:6]=[C:2]1[NH2:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 544586492-Amino-1-benzylideneamino-4-ethyl-imidazole

Product 1

HCID 189378841,2-Diamino-4-ethyl-imidazole hydrochloride

Conditions

Temperature
120 °C

Procedure

A mixture of 4.29 g (0.02 mol) of 2-amino-1-benzylideneamino-4-ethyl-imidazole and 25 ml of 2N hydrochloric acid is heated to 120° C. and subjected to steam distillation for one hour. The distillation residue is cooled and then concentrated to dryness by evaporation, and the residue is crystallized from ethanol/ethyl acetate. In that manner there is obtained the title compound, m.p. 124°-125° C., 1H-NMR (DMSO/D2 0) δ=6.53 (s, 1H); 2.36 (q, 2H); 1.07 (t, 3H).

Workup

  1. distillationsubjected to steam distillation for one hour
  2. temperatureThe distillation residue is cooled
  3. concentrationconcentrated to dryness by evaporation
  4. customthe residue is crystallized from ethanol/ethyl acetate

Sources & evidence

ORD record
ord-209718f2f0cb410892143487a3e23abc
Source dataset
uspto-grants-1998_11
Patent number
US05840911

Reaction notes

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