Sodium Hydroxide → HCID 18937663, compound

HRID 357648Notes

Reaction equation

HRID 357648 reaction equation
[CH3:1][O:2][C:3]1[CH:34]=[CH:33][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:27])[C:14]3[CH:19]=[C:18]([O:20][CH2:21][O:22][CH3:23])[CH:17]=[CH:16][C:15]=3[N+:24]([O-:26])=[O:25])=[C:11]([C:28]([O:30]CC)=[O:29])[N:10]=[N:9]2)=[CH:5][CH:4]=1.[OH-].[Na+]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:27])[C:14]3[CH:19]=[C:18]([O:20][CH2:21][O:22][CH3:23])[CH:17]=[CH:16][C:15]=3[N+:24]([O-:26])=[O:25])=[C:11]([C:28]([OH:30])=[O:29])[N:10]=[N:9]2)=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18937688HCID 18937688, compound

Product 1

HCID 18937663HCID 18937663, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl)-5-(5-methoxymethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) (1.23 g, 2.62 mmole) in tetrahydrofuran (25 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (5.2 ml) at room temperature for 5 hours to give 1-(4-methoxybenzyl)-5-(5-methoxymethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid (c-2': MP) (1.08 g, 93%)

Sources & evidence

ORD record
ord-bb701ca88f904080a03d4656bd2409ba
Source dataset
uspto-grants-1998_11
Patent number
US05840895

Reaction notes

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