Sodium Hydroxide → HCID 18937768, compound

HRID 357654Notes

Reaction equation

HRID 357654 reaction equation
[CH3:1][O:2][C:3]1[CH:33]=[CH:32][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([CH3:22])=[CH:16][C:15]=3[N+:23]([O-:25])=[O:24])=[C:11]([C:27]([O:29]CC)=[O:28])[N:10]=[N:9]2)=[CH:5][CH:4]=1.[OH-].[Na+]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([CH3:22])=[CH:16][C:15]=3[N+:23]([O-:25])=[O:24])=[C:11]([C:27]([OH:29])=[O:28])[N:10]=[N:9]2)=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18937675HCID 18937675, compound

Product 1

HCID 18937768HCID 18937768, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl )-5-(5-methoxy-4-methyl-2-nitrobenzoyl)-1,2, 3-triazole-4-carboxylate (b-2) (288 mg, 0.638 mmole) in tetrahydrofuran (7 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (1.3 ml) at room temperature for 4.5 hours to give 1-(4-methoxybenzyl)-5-(5-methoxy-4-methyl-2-nitrobenzoyl )-1,2,3-triazole-4-carboxylic acid (c-2': MP) (256 mg, 94%).

Sources & evidence

ORD record
ord-1d4cdeba20934e59bf22eefecc9e5163
Source dataset
uspto-grants-1998_11
Patent number
US05840895

Reaction notes

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