HCID 18937768, compound → HCID 21476200, compound

HRID 357655Notes

Reaction equation

HRID 357655 reaction equation
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([CH3:22])=[CH:16][C:15]=3[N+:23]([O-])=O)=[C:11]([C:27]([OH:29])=[O:28])[N:10]=[N:9]2)=[CH:5][CH:4]=1.[H][H]>C(O)C.C(OCC)(=O)C.[Pd]>[NH2:23][C:15]1[CH:16]=[C:17]([CH3:22])[C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:13]([C:12]1[N:8]([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:31][CH:30]=2)[N:9]=[N:10][C:11]=1[C:27]([OH:29])=[O:28])=[O:26]

Participants

6

Reactant 2

HCID 18937768HCID 18937768, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21476200HCID 21476200, compoundYield 92%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Next, 1-(4-methoxybenzyl)-5-(5-methoxy-4-methyl-2-nitrobenzoyl )-1,2,3-triazole-4-carboxylic acid (c-2': MP) (252 mg, 0.591 mmole) was dissolved in a mixed solvent of ethanol (10 ml) and ethyl acetate (10 ml), and reduced in the presence of 10% palladium on carbon (31 mg) under the hydrogen atmosphere at room temperature overnight to give 5-(2-amino-5-methoxy-4-methylbenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-4-carboxylic acid (c-2: MP) (216 mg, 92%).

Sources & evidence

ORD record
ord-b2997423d01a4be2851fbf1b96523215
Source dataset
uspto-grants-1998_11
Patent number
US05840895

Reaction notes

Loading…