Formic Acid → 3-Fluorobenzoyl chloride

HRID 357694Notes

Reaction equation

HRID 357694 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]([Cl:11])(Cl)Cl)[CH:5]=[CH:6][CH:7]=1.C(O)=[O:13]>[Fe](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[C:8]([Cl:11])=[O:13]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 678663-Fluorobenzotrichloride

Product 1

HCID 743763-Fluorobenzoyl chloride

Reagents, catalysts & solvents 1

HCID 24458Ferrous ChlorideCatalyst

Conditions

Temperature
80 °C

Procedure

300 g of 3-fluorobenzotrichloride and 1.5 g of iron chloride are placed in an apparatus comprising a 1 l four necked flask equipped with stirrer, thermometer, reflux condenser and dropping funnel. The mixture was heated to 80° C. A total of 53 ml of formic acid were then added over 5 hours in such a manner that the temperature could readily be maintained.

Workup

  1. customequipped with stirrer
  2. temperaturethermometer, reflux condenser
  3. temperaturecould readily be maintained

Sources & evidence

ORD record
ord-33f9cfd201e04a34a6e4ad53643cc773
Source dataset
uspto-grants-1998_11
Patent number
US05840975

Reaction notes

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