Aniline → HCID 12806756, compound

HRID 358030Notes

Reaction equation

HRID 358030 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([Cl:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[NH:13]([C:2]1[C:11]2[C:6](=[C:7]([Cl:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 2472674,8-dichloroquinazoline

Product 1

HCID 12806756HCID 12806756, compoundYield 49.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15 ml of ethanol were added to a mixture of 3.0 g of 4,8-dichloroquinazoline and 1.9 g of aniline, and then the mixture was heated. The reagents dissolved and immediately solidified. After cooling, the solidified product was collected, washed with ethanol and then recrystallized from ethanol to give 1.9 g (yield 48%) of the desired Compound No. 13 in the form of colourless crystals having a melting point of 206° C. (with decomposition).

Workup

  1. temperaturethe mixture was heated
  2. dissolutionThe reagents dissolved
  3. temperatureAfter cooling
  4. customthe solidified product was collected
  5. washwashed with ethanol
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-9b8178506e12470095f437111132c73c
Source dataset
uspto-grants-1984_08
Patent number
US04464375

Reaction notes

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