反应详情

2.5 g of 4-chloro-7-trifluoromethylquinazoline and 1.2 g of N-methylaniline were added, in turn, to 5 ml of ethanol, and then the mixture was heated until it became a homogeneous solution. At the end of this time, the ethanol was distilled off and the residual crystals were recrystallized from a 9:1 by volume mixture of ethanol and water, to give 1.4 g (yield 46%) of the desired Compound No. 73 in the form of colourless granules melting at 135°-137° C.

1. temperaturethe mixture was heated until it
2. distillationAt the end of this time, the ethanol was distilled off
3. customthe residual crystals were recrystallized from a 9:1 by volume mixture of ethanol and water