HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Mercaptopropionic Acid → 3-[(2-Amino-5-chlorophenyl)(2-fluorophenyl)methylthio]propionic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Mercaptopropionic Acid | HCID 6514 | — |
| Reactant | 2-Amino-5-chloro-alpha-(2-fluorophenyl)benzenemethanol | HCID 12900033 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-[(2-Amino-5-chlorophenyl)(2-fluorophenyl)methylthio]propionic acid hydrochloride | HCID 70509921 | — |
Reaction Steps
100 g of 2-amino-5-chloro-2'-fluorobenzhydrol, 45.6 g of 3-mercaptopropionic acid and 200 ml of 6N hydrochloric acid are stirred together at 100° for 1.5 hours. After cooling the mixture, the precipitated crystals are filtered off and washed with 6N hydrochloric acid. There is obtained 3-[(2-amino-5-chlorophenyl)(2-fluorophenyl)methylthio]propionic acid hydrochloride of melting point 139°-141°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04464300 |
| Source dataset | uspto-grants-1984_08 |
| ORD ID | ord-92802bbfc663425c842924527b62d43c |
| Source note | uspto-grants-1984_08 |