反应详情

100 g of 2-amino-5-chloro-2'-fluorobenzhydrol, 45.6 g of 3-mercaptopropionic acid and 200 ml of 6N hydrochloric acid are stirred together at 100° for 1.5 hours. After cooling the mixture, the precipitated crystals are filtered off and washed with 6N hydrochloric acid. There is obtained 3-[(2-amino-5-chlorophenyl)(2-fluorophenyl)methylthio]propionic acid hydrochloride of melting point 139°-141°.

1. temperatureAfter cooling the mixture
2. filtrationthe precipitated crystals are filtered off
3. washwashed with 6N hydrochloric acid