Pyridine → HCID 20449962, compound

HRID 358041Notes

Reaction equation

HRID 358041 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:25])[S:13][CH2:14][CH2:15][C:16](O)=[O:17].ClC(OCC)=O.N1C=CC=CC=1>O1CCCC1>[Cl:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[CH:12]1[C:4]2[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[CH:7]=[CH:8][C:3]=2[NH:2][C:16](=[O:17])[CH2:15][CH2:14][S:13]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 70508191HCID 70508191, compound

Product 1

HCID 20449962HCID 20449962, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By cyclizing 3-[(2-amino-5-nitrophenyl)(2-chlorophenyl)methylthio]propionic acid hydrochloride in analogy to Example 1(c), but in tetrahydrofuran and using ethyl chloroformate and pyridine, there is obtained 6-(2-chlorophenyl)-1,3,4,6-tetrahydro-8-nitro-2H-5,1-benzothiazocin-2-one of melting point 285°.

Sources & evidence

ORD record
ord-ae2a2acb9b2a4621ad50b736c3cf5c1e
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

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