Water → HCID 19037728, compound

HRID 358044Notes

Reaction equation

HRID 358044 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=[N:18]O)[CH2:10][CH2:9]1.[OH2:20]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:17]2[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=2[NH:18][C:11](=[O:20])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 962WaterHCID 73509636HCID 73509636, compound

Product 1

HCID 19037728HCID 19037728, compound

Procedure

26 g of 4-(2-fluorophenyl)-1-tetralone oxime are added to 130 g of polyphosphoric acid pre-heated to 125°. The solution obtained is stirred at 125° for 30 minutes, cooled, mixed with ice and water and extracted with chloroform. After evaporation of the organic phase, the residue is crystallized from ethanol. There is obtained 5-(2-fluorophenyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one of melting point 210°-212°.

Workup

  1. temperaturepre-heated to 125°
  2. customThe solution obtained
  3. temperaturecooled
  4. extractionextracted with chloroform
  5. customAfter evaporation of the organic phase
  6. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-12478248b1f147fa87fc962e1667ba2f
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

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