Ethyl isocyanate → HCID 13337913, compound

HRID 358095Notes

Reaction equation

HRID 358095 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>C1(C)C=CC=CC=1>[C:1]1([N:7]2[CH2:8][C:9](=[O:11])[N:14]([CH2:12][CH3:13])[C:15]2=[O:16])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 66025N-Phenylglycine

Product 1

HCID 13337913HCID 13337913, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of N-phenyl glycine (30.2 grams, 0.2 moles), ethylisocyanate (17.8 grams, 0.25 moles) and 30 ml of toluene was refluxed for 9 hours and allowed to stand overnight at room temperature (21° C.). The suspended product was collected by filtration and washed with toluene. After drying (21° C.) it was crystallized from ethanol to produce 17 grams (42% yield) of the above-identified product having a melting point of about 142° C.

Workup

  1. temperaturewas refluxed for 9 hours
  2. custom(21° C.)
  3. filtrationThe suspended product was collected by filtration
  4. washwashed with toluene
  5. customAfter drying (21° C.) it
  6. customwas crystallized from ethanol

Sources & evidence

ORD record
ord-aa519dd2f91746e8b99db034310ea6cb
Source dataset
uspto-grants-1984_08
Patent number
US04464387

Reaction notes

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