Sodium borohydride → 2,2-Dimethyl-5,5-dimethylthio-4-(1,2,4-triazol-1-yl)-pent-4-en-3-ol

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Reaction Steps

15 g (0.055 mol) of 2,2-dimethyl-5,5-dimethylthio-4-(1,2,4-triazol-1-yl)-pent-4-en-3-one (obtained as described in Example 1) were dissolved in 100 ml of methanol, and 2.1 g (0.055 mol) of sodium borohydride were added at room temperature. The mixture was stirred for a further 30 minutes at 20° to 30° C., and was concentrated. The residue was partitioned between methylene chloride and water. The organic phase was separated off, dried over sodium sulphate and concentrated. 11.9 g (80% of theory) of 2,2-dimethyl-5,5-dimethylthio-4-(1,2,4-triazol-1-yl)-pent-4-en-3-ol of melting point 108° to 111° C. were obtained.

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