反应详情

3-Amino-1-(4-chlorophenyl)-2-pyrazoline (1.5 g) (prepared in Reference Example 6 of our European patent specification No. 22-578) and methylisothiocyanate (1.02 g) were heated together at 100° for two hours. The crude product was ground under methanol, collected by filtration, and recrystallised from acetone to yield 3-(3-methylthioureido)-1-(4-chlorophenyl)-2-pyrazoline, m.p. 237°.

1. filtrationcollected by filtration
2. customrecrystallised from acetone