Methyl isothiocyanate → HCID 178486106, compound

HRID 358216Notes

Reaction equation

HRID 358216 reaction equation
[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:3]=1.[CH3:14][N:15]=[C:16]=[S:17]>>[CH3:14][NH:15][C:16](=[S:17])[NH:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 11167Methyl isothiocyanateHCID 125514501-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine

Product 1

HCID 178486106HCID 178486106, compound

Procedure

3-Amino-1-(4-chlorophenyl)-2-pyrazoline (1.5 g) (prepared in Reference Example 6 of our European patent specification No. 22-578) and methylisothiocyanate (1.02 g) were heated together at 100° for two hours. The crude product was ground under methanol, collected by filtration, and recrystallised from acetone to yield 3-(3-methylthioureido)-1-(4-chlorophenyl)-2-pyrazoline, m.p. 237°.

Workup

  1. filtrationcollected by filtration
  2. customrecrystallised from acetone

Sources & evidence

ORD record
ord-f7322818cc2c48fba8a956de47e50faf
Source dataset
uspto-grants-1984_08
Patent number
US04465685

Reaction notes

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