反应详情

A slurry of 2.00 g (5.12 mmoles) of 6-(m-trimethylsilylethynylphenyl)benzimidazoquinazoline and 200 mg of anhydrous potassium carbonate in 100 ml of anhydrous methanol was stirred at 25° for 3 hours. The solvent was removed and the residue was dissolved in 100 ml of chloroform, washed with 100 ml of 5% hydrochloric acid and then with 100 ml of water. The organic phase was dried over magnesium sulfate and concentrated to give a yellow solid which was recrystallized from ether-hexane. Yield: 1.55 g (4.86 mmoles, 94.9%): ir (KBr) 3300 cm-1 (medium, sharp, C≃C--H); mass spectrum (70 ev) m/e 319 (molecular ion).

1. customThe solvent was removed
2. dissolutionthe residue was dissolved in 100 ml of chloroform
3. washwashed with 100 ml of 5% hydrochloric acid
4. dry with materialThe organic phase was dried over magnesium sulfate
5. concentrationconcentrated
6. customto give a yellow solid which
7. customwas recrystallized from ether-hexane