Methylamine → HCID 178484896, compound

HRID 358259Notes

Reaction equation

HRID 358259 reaction equation
[C:1]([NH:3][CH:4]=[N:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[CH:14][NH:15][CH:16]=2)=[CH:8][CH:7]=1)#N.CN>O>[CH3:1][NH:3][CH:4]=[N:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[CH:14][NH:15][CH:16]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178512241HCID 178512241, compound

Product 1

HCID 178484896HCID 178484896, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Twenty grams of N-cyano-N'-[4-(imidazol-4-yl)-phenyl]-formamidine was added in one portion to 35% methylamine in water (70 ml). A few minutes after the addition, the solid N-methyl-N'-[4-(imidazol-4-yl)-phenyl]-formamidine separated out of the solution. This solid was collected by filtration, washed with water, and dried to yield 13.45 gm of the desired product, which was recrystallized from acetone.

Workup

  1. additionA few minutes after the addition
  2. customthe solid N-methyl-N'-[4-(imidazol-4-yl)-phenyl]-formamidine separated out of the solution
  3. filtrationThis solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-d2f00d457ee1433c843a464d5043d005
Source dataset
uspto-grants-1984_08
Patent number
US04465841

Reaction notes

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