Methyl isothiocyanate → HCID 178486097, compound

HRID 358262Notes

Reaction equation

HRID 358262 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[CH3:13][N:14]=[C:15]=[S:16]>C(O)C>[CH3:13][NH:14][C:15]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1)=[S:16]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 178507418HCID 178507418, compound

Product 1

HCID 178486097HCID 178486097, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.3 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.15 gm of methyl isothiocyanate in 30 ml of ethanol was refluxed for thirty minutes and evaporated to dryness. The oily base so obtained was purified by conversion into the corresponding hydrochloride salt by bubbling gaseous hydrochloric acid in isopropanol. The desired thiourea was obtained as a white solid.

Workup

  1. customevaporated to dryness
  2. customThe oily base so obtained
  3. customwas purified by conversion into the corresponding hydrochloride salt
  4. customby bubbling gaseous hydrochloric acid in isopropanol

Sources & evidence

ORD record
ord-3b6a72acc242468fa129b70ab27e32a6
Source dataset
uspto-grants-1984_08
Patent number
US04465841

Reaction notes

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