[(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid → 2-Butyl-6,7-dichloro-2-cyclopentyl-5-hydroxy-1-indanone

HRID 358275Notes

Reaction equation

HRID 358275 reaction equation
ClC1C(Cl)=C2C(CC(C3CCCC3)(C)C2=O)=CC=1OCC(O)=O.[CH2:24]([C:28]1([CH:45]2[CH2:49][CH2:48][CH2:47][CH2:46]2)[CH2:36][C:35]2[C:30](=[C:31]([Cl:43])[C:32]([Cl:42])=[C:33]([O:37]CC(O)=O)[CH:34]=2)[C:29]1=[O:44])[CH2:25][CH2:26][CH3:27]>>[CH2:24]([C:28]1([CH:45]2[CH2:49][CH2:48][CH2:47][CH2:46]2)[CH2:36][C:35]2[C:30](=[C:31]([Cl:43])[C:32]([Cl:42])=[C:33]([OH:37])[CH:34]=2)[C:29]1=[O:44])[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 3667[(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetic acidHCID 5017((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid, (+)-

Product 1

HCID 127611362-Butyl-6,7-dichloro-2-cyclopentyl-5-hydroxy-1-indanone

Procedure

By following substantially the procedure in Example 8, Step A, but substituting for (+)[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]acetic acid an equimolar quantity of (+)[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid, there is obtained (+)2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-5-hydroxy-1H-inden-1-one which is used in Step C without further purification.

Sources & evidence

ORD record
ord-ab50f5bdfad94891969c7446d3351bf9
Source dataset
uspto-grants-1984_08
Patent number
US04465850

Reaction notes

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