((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid, (+)- → 2-Butyl-6,7-dichloro-2-cyclopentyl-5-hydroxy-1-indanone

HRID 358277Notes

Reaction equation

HRID 358277 reaction equation
[CH2:1]([C:5]1([CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:13][C:12]2[C:7](=[C:8]([Cl:20])[C:9]([Cl:19])=[C:10]([O:14]CC(O)=O)[CH:11]=2)[C:6]1=[O:21])[CH2:2][CH2:3][CH3:4]>C(O)(=O)C>[CH2:1]([C:5]1([CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:13][C:12]2[C:7](=[C:8]([Cl:20])[C:9]([Cl:19])=[C:10]([OH:14])[CH:11]=2)[C:6]1=[O:21])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 5017((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid, (+)-

Product 1

HCID 127611362-Butyl-6,7-dichloro-2-cyclopentyl-5-hydroxy-1-indanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

By following substantially the procedure in Example 8, Step A, but substituting for (+) 6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]acetic acid an equimolar quantity of (-) [(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid, there is obtained (-) 2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-5-hydroxy-1H-inden-1-one which is used in Step C without further purification.

Sources & evidence

ORD record
ord-78f0b3fb1a0e4da69c69c1be9dfdadd1
Source dataset
uspto-grants-1984_08
Patent number
US04465850

Reaction notes

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