Hydrogen Bromide → HCID 70502727, compound

HRID 358306Notes

Reaction equation

HRID 358306 reaction equation
C([O:14][C:15](=[O:40])[CH:16]([CH:33]1[CH2:37][C:36](=[O:38])[NH:35][C:34]1=[O:39])[NH:17][C:18](=[O:32])[C@H:19]([CH3:31])[NH:20]C(OCC1C=CC=CC=1)=O)(C1C=CC=CC=1)C1C=CC=CC=1.[BrH:41].C(OCC)C>C(O)(=O)C>[BrH:41].[NH2:20][C@H:19]([C:18]([NH:17][CH:16]([CH:33]1[CH2:37][C:36](=[O:38])[NH:35][C:34]1=[O:39])[C:15]([OH:40])=[O:14])=[O:32])[CH3:31]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 70503253HCID 70503253, compound

Product 1

HCID 70502727HCID 70502727, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 5.3 g of benzyloxycarbonyl-L-alanyl-2-(2,5-dioxopyrrolidin-3-yl)glycine benzhydryl ester was added 10 ml of a 30% solution of hydrogen bromide in acetic acid and the mixture was stirred at room temperature for one hour. To the reaction mixture was added ethyl ether and the resulting precipitate was collected by filtration. Yield 3.2 g.

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-3c5a111c4ff346fda872975b9b23e6de
Source dataset
uspto-grants-1984_08
Patent number
US04465844

Reaction notes

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