3-Amino-4-methoxycyclobut-3-ene-1,2-dione → HCID 20448693, compound

HRID 358336Notes

Reaction equation

HRID 358336 reaction equation
[NH2:1][C:2]1[C:5](=O)[C:4](=[O:7])[C:3]=1[O:8]C.[CH3:10][N:11]([CH2:13][C:14]1[CH:19]=[CH:18][N:17]=[C:16]([O:20][CH2:21][CH2:22][CH2:23][NH2:24])[CH:15]=1)[CH3:12]>C(O)C>[CH3:10][N:11]([CH2:13][C:14]1[CH:19]=[CH:18][N:17]=[C:16]([O:20][CH2:21][CH2:22][CH2:23][NH:24][C:5]2[C:4](=[O:7])[C:3](=[O:8])[C:2]=2[NH2:1])[CH:15]=1)[CH3:12]

Participants

4

Reactant 2

HCID 134522053-Amino-4-methoxycyclobut-3-ene-1,2-dioneHCID 14625101HCID 14625101, compound

Product 1

HCID 20448693HCID 20448693, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Amino-2-methoxy-cyclobut-1-ene-3,4-dione (0.5 g) and 3-[4-(dimethylaminomethyl)pyrid-2-yloxy]prop-1-yl-amine (0.85 g) were refluxed in ethanol in a similar manner to Example 1. The solid obtained was recrystallised from ethanol to give the title product, (0.79 g), m.p. 212°-4° C.

Workup

  1. customThe solid obtained
  2. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-13b4d6e8bb72484dba5827d624dd1bbf
Source dataset
uspto-grants-1984_08
Patent number
US04466970

Reaction notes

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