3-Amino-4-methoxycyclobut-3-ene-1,2-dione → 1-[3-[4-(Piperidinomethyl)pyrid-2-yloxy]prop-1-ylamino]-2-aminocyclobut-1-ene-3,4-dione

HRID 358338Notes

Reaction equation

HRID 358338 reaction equation
[NH2:1][C:2]1[C:5](=O)[C:4](=[O:7])[C:3]=1[O:8]C.[N:10]1([CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([O:23][CH2:24][CH2:25][CH2:26][NH2:27])[CH:18]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>N1C=CC=CC=1>[N:10]1([CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:5]3[C:4](=[O:7])[C:3](=[O:8])[C:2]=3[NH2:1])[CH:18]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 134522053-Amino-4-methoxycyclobut-3-ene-1,2-dioneHCID 146251023-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine

Product 1

HCID 204486941-[3-[4-(Piperidinomethyl)pyrid-2-yloxy]prop-1-ylamino]-2-aminocyclobut-1-ene-3,4-dione

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-Amino-2-methoxy-cyclobut-1-ene-3,4-dione is mixed with 3-[4-(piperidinomethyl)pyrid-2-yloxy]prop-1-ylamine in anhydrous pyridine and is heated at reflux temperature to give the title product.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature

Sources & evidence

ORD record
ord-e1531e787e9b43b0a36bbccd9a32a89d
Source dataset
uspto-grants-1984_08
Patent number
US04466970

Reaction notes

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