HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-t-Butyldimethylsilyloxy-2-(6-acetoxyhexylthio)-2-cyclopentenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | HCID 20448815 | HCID 20448815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-t-Butyldimethylsilyloxy-2-(6-acetoxyhexylthio)-2-cyclopentenone | HCID 20448814 | 96.5% |
Reaction Steps
700 mg (2.13 mmoles) of 4(RS)-t-butyldimethylsilyloxy-2-(6-hydroxyhexylthio)-2-cyclopentenone, 1020 mg (10 mmoles) of acetic anhydride and 1580 mg (20 mmoles) of pyridine were mixed, and stirred at room temperature for 2 hours. After the reaction, methanol was added. The solvent was removed to give 795 mg of 4-t-butyldimethylsilyloxy-2-(6-acetoxyhexylthio)-2-cyclopentenone as a nearly pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04466980 |
| Source dataset | uspto-grants-1984_08 |
| ORD ID | ord-102cf2f0862645dcbe7eff90fd1985d5 |
| Source note | uspto-grants-1984_08 |