反应详情

A mixture of 8.26 g of ethyl 4-aminobenzoate, 8.26 g of N-chlorosuccinimide in 50 ml of dichloromethane is refluxed overnight. The mixture is washed with saturated NaHCO3 solution and dried (Na2SO4). The solution is passed through a thin pad of hydrous magnesium silicate and the filter cake washed with dichloromethane. The filtrate is concentrated and hexane added. Chilling gives 7.38 g of ethyl 3-chloro-4-aminobenzoate, m.p. 82°-83° C.

1. temperatureis refluxed overnight
2. washThe mixture is washed with saturated NaHCO3 solution
3. dry with materialdried (Na2SO4)
4. washthe filter cake washed with dichloromethane
5. concentrationThe filtrate is concentrated
6. additionhexane added
7. temperatureChilling