HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 8-fluoro-N-[2-[4-(i-propyl)phenyl]ethyl]-4-quinazolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-(Propan-2-yl)phenyl)ethan-1-amine | HCID 410082 | — |
| Reactant | 4-Chloro-8-fluoroquinazoline | HCID 19939133 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-fluoro-N-[2-[4-(i-propyl)phenyl]ethyl]-4-quinazolinamine | HCID 19939119 | — |
Reaction Steps
A mixture of 2 g of 4-chloro-8-fluoroquinazoline, 1.94 g of 2-[4-(i-propyl)phenyl]ethylamine, and 1.21 g of triethylamine in 100 mL of ethanol was heated at reflux for one hour. The ethanol was removed and the remaining product was dissolved in 100 mL of methylenechloride and then washed with aqueous sodium carbonate. The organic layer was then dried and the solvent was removed. The residue was slurried in pentane. Yield: 2.4 g. M.P. 170°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411963 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-22ecffae32f44ed6aca698ab258374de |
| Source note | uspto-grants-1995_05 |